The finding that certain compounds (ANI-7 (1), NAP-6 (2), aminoflavone) to induce growth inhibition in a select panel of breast cancer cell lines and other ER positive cell lines (i.e., A431 skin and H460 lung), while having minimal to no effect in cell lines derived from other tumour types has previously been presented by us and others. This evidence concerns the gene ESR1 and breast carcinoma.