While induction of AhR activity is required to stimulate CYP-induced metabolic activation of 1, 2 and 3 (Gilbert et al., 2017; Gilbert et al., 2020), the magnitude of AhR induction by the BBQ analogues did not directly correlate with the potency of growth inhibition or to tumour type selectivity. The gene discussed is PPIG; the disease is neoplasm.