AKT1 and type 2 diabetes mellitus: Under physiological conditions, activation of amylin receptors results in downstream cellular signaling via the ERK1/2 and Akt pathways (Visa et al., 2015; Fu et al., 2017) but, under conditions where blood glucose levels are high, such as in T2D, these signaling pathways are inhibited by activation of amylin receptors (Visa et al., 2015).