LDLR and atherosclerosis: Trem2 deficiency increased necrotic core formation in early atherosclerosis in mice with no changes in systemic lipid parameters (BM chimeras, 12 weeks of HFD, and Ldlr−/−Trem2−/− mice, 10 weeks of HFD) but also in mice showing decreased total cholesterol and triglyceride levels (Trem2−/− BM chimeras, 8 weeks of HFD), indicating that increased necrotic core formation is not driven by dyslipidemia.