As a repeat PSA test for men with suspected PCa and PSA of 3–10 ng/ml is currently recommended before further investigations, inclusion of ΔPSA information in a multivariable MRI-RC or in a dichotomous biopsy decision rule improves risk stratification of men for biopsy without necessitating additional diagnostic tests [1]. This evidence concerns the gene KLK3 and posterior cortical atrophy.