For example, the activation of the NF-κB pathway causing DLBCL (Odqvist et al., 2014), the deregulation of the JAK-STAT pathway and PI3K-mediated signaling pathway which is the essential contributor to the pathogenesis and poor prognosis of DLBCL (Chapuy et al., 2018) (Supplementary Figure S1). This evidence concerns the gene NFKB1 and diffuse large B-cell lymphoma.