Finally, Since COPS5 has been shown to be associated with the proliferation of DLBCL in several cell lines derived from subtypes of DLBCL (Pulvino et al., 2015), to further determine the role of COPS5 in B cell lymphoma, we depleted COPS5 in the B cell lymphoma cell lines Raji and SLVL using the CRISPR/Cas9 system. The gene discussed is COPS5; the disease is diffuse large B-cell lymphoma.