The FVL (F5 gene mutation 1691G > A (rs6025)) results in an altered variant of factor V, which enhance resistance to inactivation by protein C and hypercoagulable state with a five-to-tenfold risk of thrombosis in heterozygote and an 80-fold risk in homozygote individuals 5,6. This evidence concerns the gene F5 and deep vein thrombosis.