As we stated before; biomarkers defining malignancy degree still not universally established, and studies' results remain sometimes controversial, therefore, in the present study, we analysed CD10 and EGFR proteins expression, correlating them with some biopathologic parameters with the aim of obtaining insight on the behave of these two proteins on the tumor especially when they are both overexpressed in the same patient's tumor. The gene discussed is EGFR; the disease is neoplasm.