More interesting, our findings suggest the aggressive potential of tumors behaviour with simultaneous CD10 and EGFR expression since tumors were malignant, CD 10 and EGFR co expression was noted in head and neck squamous cell carcinoma20 and in basal breast cell lines21, our results may indicate that multiple signalling pathways are simultaneously active in this phyllode tumor type, in fact, amplified EGFR interplay with caveolin-1, eps15, pAkt, mdm2 and pERK and seems to present a major molecular pathway in carcinogenesis and progression of breast phyllodes tumours22 . This evidence concerns the gene MME and phyllodes tumor.