BRCA1 and neoplasm: Germline pathogenic and likely pathogenic variants (herein called pathogenic variants, PVs) in the tumour suppressor genes BRCA1 and BRCA2 are predominantly associated with a significantly increased risk of breast and ovarian cancer in women, breast cancer (BC) and prostate cancer (PCa) in men, and pancreatic cancer (PC) and melanoma in both genders, with different risk rates (1).