BRCA1 and breast carcinoma: Finally, our study also analyzed gene location of the germline BRCA PVs, in order to investigate eventual associations between specific variants and tumor phenotype, since several studies suggested a strong correlation between specific BRCA1/2 variants and changes in breast and ovarian cancer relative risk, by identifying specific putative Breast Cancer Cluster Regions (BCCRs) and Ovarian Cancer Cluster Regions (OCCRs), located on the coding DNA sequences of BRCA1 and BRCA2 genes (36–39).