Furthermore, we investigated the presence of VUS and other variants with conflicting interpretations of pathogenicity (CIP) in BRCA1/2 genes of 352 individuals, identifying 9 different VUS/CIP (4 in BRCA1 and 5 in BRCA2) in 9 patients, 3 of which had MBC, 3 showed PCa, and 3 were affected by PC. Here, BRCA1 is linked to pachyonychia congenita.