The evaluation of stroke severity in IS patients revealed that the Malat1 expressionsignificantly was lower (2.7±0.51 vs 5±1.3, P=0.001) in patients with high NIHSSscore (>7),while IL-1β was higher in patients with NIHSS 0-6 (65.3±7.7 vs 35.1±2.9, P=0.000). The gene discussed is MALAT1; the disease is stroke disorder.