Evan et al. reported that the expression of IL-1β, IL-6, TGF-β, IL-23a, and NADPHoxidase-2 wasdecreased after ischemic stroke in the brains of mice supplemented with 1,25-VitD3and alsodemonstrated that expression of the 1-α-hydroxylase as a vitamin D-activating enzymewasdecreased, while expression of 24-hydroxylase (vitamin D inactivating enzyme), wasincreased inbrain and spleen after a stroke [37]. The gene discussed is IL1B; the disease is Stroke.