The peptides we previously found that improve cognitive decline induced by HFD intake increase other neurotrophic factors in the hippocampus; YLG, derived from αS1‐casein, increases NGF and CTNF, and rice‐memolin, derived from rice bran, increases EGF and FGF‐2, and slightly increase NGF, NT‐3, and GDNF. The gene discussed is NTF3; the disease is Mental deterioration.