The peptides we previously found that improve cognitive decline induced by HFD intake increase other neurotrophic factors in the hippocampus; YLG, derived from αS1‐casein, increases NGF and CTNF, and rice‐memolin, derived from rice bran, increases EGF and FGF‐2, and slightly increase NGF, NT‐3, and GDNF. Here, PTGDR is linked to Mental deterioration.