On the contrary, the inhibition of the NF-κB pathway leads to the upregulation of anti-inflammatory factors and the M2 polarization of reprogrammed macrophage, thus contributing to the prevention and treatment of some disease, such as liver inflammation and acute myocardial infarction (Li et al., 2020; Cai et al., 2022; Zhao et al., 2022). Here, NFKB1 is linked to acute myocardial infarction.