MAPK8 and pancreatic adenocarcinoma: GSK-3β is known to be phosphorylated and inactivatedby the phosphoinositide 3 kinase (PI3K/AKT) pathway.17 GSK-3β has been reported to promote cell growth andsurvival in colon, breast, ovarian, and pancreatic adenocarcinomas.Therefore, we used a specific GSK3 inhibitor SB216763 and found thatSB protected lung adenocarcinoma A549 cells from cisplatin in boththe absence (Figure 7g) and presence (Figure 7h) of JNK inhibition.