Amyloid plaques are one of the hallmarks of AD4 and are mainly composed of β-amyloid peptides(Aβs), which are derived from the APP.5 The triggering receptor expressed on myeloid cells 2 (TREM2) isa transmembrane protein that is thought to be related to AD in twosignificant ways. This evidence concerns the gene TREM2 and Alzheimer disease.