By employing siRNAs to block these genes, autophagywas suppressed, as was seen by a reduced concentration of autophagosomes.Consequently, radiation-resistant cancer cells become increasinglysusceptible to it.211 In one study, usingsiRNA to reduce Beclin-1 increased PARP breakage, mitochondrial membranedepolarization, and cytosolic cytochrome c levels following doxorubicintherapy. The gene discussed is BECN1; the disease is cancer.