ATG7 and cancer: Inhibiting autophagy has been demonstrated to significantlyreduce the viability of cancer cells and increase apoptosis.88 Similar findings were found whereby blockingautophagy with ATG-7 siRNA caused epirubicin’s cytotoxicityto rise in a number of breast cancer cells, along with an increasein caspase-9- and caspase-3-dependent apoptosis.157