ATG5 and cancer: Inhibitingthe drug-related autophagy, as a result, made cancer cells more sensitiveto it.214 Similar results were seen whenBeclin-1 or ATG-5 siRNA were used to block autophagy in renal cellcarcinoma (RCC) cells, increasing the sensitivity of cancer cellsto sorafenib.215 Likewise, it has beendiscovered that linifanib, an effective drug with significant anticanceractions in a variety of solid tumors,216 induces a high amount of autophagy in HCC cells.