The differences in ISG expression were not dependent on changes in IFN gene expression, as Ifnl3, Ifnb1, and Ifna12 were not vastly altered throughout the course of infection (days 1, 2, 3, or 5 p.i.)between WT and Ifnlr1–/– mice (Figure 2E). The gene discussed is IFNLR1; the disease is infection.