To better understand how endogenous type III IFN signaling confers protection against SARS-CoV-2 challenge, we performed global transcriptomic analysis on lungs of WT and Ifnlr1–/– mice following infection (Supplemental Figure 1D; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.171830DS1). Here, IFNLR1 is linked to infection.