NK cell depletion in Cd8–/– mice resulted in the shortest survival time in tumor-bearing mice when treated with the anti-FGL1 mAb (Figure 10, E and F), further indicating the critical antitumor roles of NK cells in liver metastasis and their dependence on CD8+ T cells to show the therapeutic effects of anti-FGL1 antibody blockade. The gene discussed is FGL1; the disease is neoplasm.