COMMD3 and colorectal carcinoma: The Kelleher group integrated TDP and BUP to study patient-derived breast tumor xenografts and demonstrated the significance of TDP in acquiring aberrations of cancers at the proteoform level.152 The Sun group performed a comprehensive TDP study of a pair of metastatic and nonmetastatic CRC cell lines (SW480 and SW620 cells).5 It revealed the drastic transformation of CRC cells in proteoform profiles after metastasis, Fig. 4.