TARDBP and frontotemporal dementia: The DeMarco group recently introduced their work using targeted qualitative and quantitative MS to discover frontotemporal lobar degeneration (FTLD)-specific TDP-43 proteoforms.160 They found truncated TDP-43 proteoforms, especially C-terminal fragments, were highly enriched in FTLD-TDP cases, which can serve as a biomarker with high diagnostic accuracy.