The Kelleher group integrated TDP and BUP to study patient-derived breast tumor xenografts and demonstrated the significance of TDP in acquiring aberrations of cancers at the proteoform level.152 The Sun group performed a comprehensive TDP study of a pair of metastatic and nonmetastatic CRC cell lines (SW480 and SW620 cells).5 It revealed the drastic transformation of CRC cells in proteoform profiles after metastasis, Fig. 4. This evidence concerns the gene COMMD3 and cancer.