In severe-OSA patients, melatonin showed negative correlations with the AHI (r = −0.29, p < .05), ZO-1 level (r = −0.46, p < .01), LPS level (r = −0.35, p < .01) and CRP level (r = −0.30, p < .05) (Figure 3). The gene discussed is CRP; the disease is obstructive sleep apnea syndrome.