MDH2 and gastrointestinal stromal tumor: Several studies currently indicate that palmitoylation can either promote or inhibit the ubiquitination of substrate proteins.[22] After reviewing the literature, we discovered that MDH2 expression can be regulated by ZDHHC18‐mediated palmitoylation.[19] Subsequently, we validated this conclusion, revealing that ZDHHC18‐mediated palmitoylation of MDH2 can synergize with its UPS5‐mediated deubiquitination in GIST cell lines.