Several studies have revealed that palmitoylation might influence downstream protein degradation by affecting protein ubiquitination,[22] and MDH2 can be palmitoylated by ZDHHC18.[19] Thus, we hypothesized that ZDHHC18‐mediated palmitoylation at C138 influences the ubiquitination of MDH2 in GIST cells. Here, MDH2 is linked to gastrointestinal stromal tumor.