DCAF7 is identified as a key chemoresistance gene enhancing cisplatin resistance and metastasis in NPC, serving as a scaffold that recruits USP10 to eliminate K48‐linked ubiquitin moieties from Lys76 of G3BP1, thus promoting the formation of stress granule‐like structures. This evidence concerns the gene G3BP1 and nasopharyngeal carcinoma.