Previous studies have indicated that ANXA2 serves as a direct target of bleomycin in interstitial pulmonary fibrosis, forming a complex with transcription factor EB (TFEB) and tyrosine 3‐monooxygenase/tryptophan 5‐monooxygenase activation protein (YWHA) in the cytoplasm, resulting in the cytoplasmic retention of TFEB.[20] TFEB has been reported to be an autophagy gene involved in lysosome biogenesis and autophagolysosome regulation. Here, ANXA2 is linked to pulmonary fibrosis.