However, most patients develop drug resistance.[1] The best‐studied mechanisms of resistance to PARPi include drug target‐related resistance,[5, 30] restoration of homologous recombination,[31] restoration of replication fork stability,[32] and removal of inhibitors from the cell by efflux transporters.[33] Few studies have investigated the mechanism by which cancer cells escape the cytotoxic effects of PARP1 trapping. This evidence concerns the gene PARP1 and cancer.