Enhanced DDR is an essential signature of PARPi‐resistant cancer cells.[1] In addition, PARP1 trapping could create DNA break sites occupied by PARP1 proteins and inhibit the subsequent DDR by preventing functional molecules (for example, RAD51 and PALB2) from binding to the DNA lesions.[4, 25] Here, DDR ability was determined by comet assays and quantification of γH2AX‐PS139 foci. Here, PALB2 is linked to cancer.