αBC isupregulated in Alzheimer’s disease, dementia with Lewy bodiesand Parkinson’s disease and is found to be colocalized withthe amyloid plaques of Alzheimer’s patients.23,24 At the same time, it has been shown that αBC modulates Aβ-inducedcytotoxicity.25−28. This evidence concerns the gene ABCB6 and early-onset autosomal dominant Alzheimer disease.