CHGA and melanoma: Although the characteristics of Schwann cells can be detected in nevi, this phenotype is never adopted in malignant melanoma.[18] Even for the neuroendocrine features common in other tumors, their markers CHGA, SYN, and CD56 are considered to have no prognostic significance in melanomas.[19] Clinically, rare melanocytic tumors such as melanocytic schwannomas and melanocytic nerve sheath tumors are usually benign,[20, 21] although their origin remains controversial.