Transcriptome sequencing of EGR3‐expressing A375 melanoma cells revealed significant up‐regulation of multiple genes associated with the extracellular matrix (ECM), such as COL1A1, COL5A3, and FN1, thereby confirming the regulatory role of EGR3 in the remodeling of the extracellular space. This evidence concerns the gene EGR3 and melanoma.