CD4 and systemic lupus erythematosus: In contrast, compared with HCs, SLE sufferers had lower proportions of Tregs [0.75 (0.25–1.24) vs. 2.08 (1.37–2.51), respectively, P = 0.001], Tfh cells [0.39 (0.27–0.57) vs. 0.57 (0.42–0.75), respectively, P = 0.018] and Naïve CD4+T cells [19.35 (12.12–33.50) vs. 35.24 (25.38–43.41), respectively, P = 0.004] (Fig. 2 c-e).