TP53 and neoplasm: Following these pioneer studies, in the beginning of 2000s, many other tumor suppressor miRNAs were described such as miR-15a and miR-16-1 in B-CLL [67], and miR-34a induced by p53 [68], or oncogenic miRNAs, such as the miR-17 ~ 92 cluster (aka OncomiR-1) induced by c-Myc [69].