TP53 and cancer: In Fig. 1, we schematically depicted the complex interaction of selected miRNAs and the hallmarks of cancer and, in particular, we showed: (i) relevant miRNAs targeting proliferative signaling i.e. ROS1 (miR-750), EML4-ALK (miR-96), PI3K/AKT (miR-200c), and EGFR signaling (let-7); (ii) miRNAs involved in LC growth suppression through regulation of TP53 (miR-660), and E2F (miR-16) regulation; (iii) miRNAs involved in replicative immortality through TERT complex (miR-299) and DNA methylation (mir-29) regulation.