In vitro and in vivo results indicated CUR/miR155@DssD-Hb NPs can effectively inhibit 4T1 and B16F10 tumor cell viability, induce DAMPs release, promote the maturation of DCs and subsequent CD8+ T cell activation and infiltration, and deplete immunosuppressive cells, and reduce pulmonary metastatic nodules. Here, CD8A is linked to neoplasm.