TPO and hypothyroidism: Both anti-TPO antibody and anti-Tg antibody were associated with an increased risk for hypothyroidism, with a weighted pooled RR of 1.92 (95% CI, 1.49-2.48; P<0.001) and 1.53 (95% CI, 1.40-1.88; P<0.001) respectively (Sup.