CSF3 and central precocious puberty: We observed three immune markers between CPP alone and controls that were decreased, granulocyte colony-stimulating factor (G-CSF) (q = 0.049), regulated on activation, normal T cell expressed and secreted (RANTES) (q = 0.049), and vascular endothelial growth factor (VEGF) (q = 0.049), while interleukin-1 receptor antagonist (IL-1Ra) (q = 0.049), was elevated (Fig. 3A, E, Additional file 4: Table S20).