Elevated percentages of pEVs (CD63+CD41+) were shown in patients with active SLE (66.94 ± 10.01%, Fig. 1H), compared to those in inactive SLE patients (54.38 ± 7.62%, P < 0.005) or HC subjects (17.89 ± 6.45%, P < 0.005). This evidence concerns the gene ITGA2B and systemic lupus erythematosus.