To validate the practicality of the TaqTth-hpRNA to silence the APPswe in the mouse model of AD, the CAG promoter was replaced with the neuron-specific synapsin I (Syn) promoter (Fig. 4G), then produced AAV9 viral particles and named as AAV-TaqTth-NT (containing NT hpRNAs) and AAV-TaqTth-T (containing targeting hpRNAs), respectively. Here, SYN1 is linked to Alzheimer disease.