NOTCH1 and acute lymphoblastic leukemia: In keeping with this, CIMP leukemias also exhibited increased methylation at NOTCH1, MYB, and TAL1 binding sites than ETP-ALL, and hypomethylation of TFBS for myeloid master regulators such as CEBPA, CEBPB, and SPI1 (Supplementary Fig. 7b, Supplementary Data 28).