Several epigenetic modulators are recurrently mutated in acute myeloid leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL), including methylation regulators (DNMT3A, TET2, IDH1/2) and histone writers (EZH2, SUZ12, KMT2A, KDM6A)1,2. Here, KDM6A is linked to acute myeloid leukemia.