Given the prominent role of CTCF in the stabilization of cohesin-mediated chromatin loops42,43, we conducted in situ Hi-C experiments on CIMP (n = 9), AML (n = 5), T-ALL (n = 4) and HSPCs (n = 3) to assess changes in 3D genome organization. Here, CTCF is linked to acute lymphoblastic leukemia.