CTCF and acute myeloid leukemia: As expected, CTCF levels genome-wide were higher in regions with low DNA methylation (Fig. 6b) and gain of DNA methylation in CIMP cases correlated with loss of CTCF binding in the same regions relative to AML (rho = −0.27, p value < 2.2 × 10−16) (Fig. 6d, Supplementary Data 39).