In all three cases, the results were in line with the differential motif activity inferred from open chromatin: CEBPA binding was completely absent in CIMP and T-ALL, and SPI1 exhibited higher binding in CIMP than in T-ALL, whereas the reverse was true for TCF7 (Supplementary Fig. 9a, b). The gene discussed is SPI1; the disease is acute lymphoblastic leukemia.