CTCF and acute myeloid leukemia: When comparing CIMP and AML, we found 61 ΔTADs containing differentially expressed genes with loss of CTCF binding at their boundaries and 71 differential enhancer-promoter loops, whose interaction strength strongly correlated with the expression of genes they contacted (rho = 0.67, p = 1.8 × 10−10, Fig. 7f).