SPI1 and acute myeloid leukemia: In keeping with the GSEA results, we detected a strong enrichment for binding of the PRC2 complex at hypermethylated regions relative to AML, but also for hematopoietic factors like RUNX1, CBFB, SPI1 or GATA1, as well as CTCF and cohesin (Fig. 5a, Supplementary Fig. 7a left side, Supplementary Fig. 7c, Supplementary Data 26, Supplementary Data 29).