IRF4 and acute myeloid leukemia: A total of 100 TFs with silenced promoters were downregulated relative to AML, including hematopoietic regulators and genes known to be involved in leukemia, such as CEBPA, CEBPD, KLF4, IRF4 or MEIS1 (Fig. 4a, b, Supplementary Fig. 6a, b, Supplementary Data 23).