Collecting evidence demonstrated that the infiltration of inflammatory cells, and accompanied by increased expression of monocyte chemoattractant protein-1(MCP-1), interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) are involved in the renal fibrosis process [4]. The gene discussed is TNF; the disease is renal fibrosis.