We also identified a large population of macrophages in uveal melanoma metastatic samples (Supplementary Fig. 5e), which expressed high levels of CCR2 (Fig. 4d, f), a receptor for monocyte chemoattractant protein-1, and LGALS2. Therefore, this state was named early-stage macrophage (Mac_ES n = 4073). This evidence concerns the gene CCR2 and uveal melanoma.