LIPA and colorectal neoplasm: Another two macrophage clusters with a lipid-associated (LA) metabolism transcriptional signature (Fig. 4d–g), including genes such as FABP5, LPL, and LIPA, named RTM_LA (n = 3569) and Mac_LA (n = 1249), were found enriched in breast, lung, and colorectal tumors (Supplementary Fig. 5d–f).