Indeed, DG appears to be involved in several cellular mechanisms such as motility, survival and cell proliferation and an imbalance in its homeostasis or in the functioning of its effectors, especially protein kinase C (PKC), seems to be involved in the progression and development of metastasis.46 In a study on triple-negative breast cancer, high expression of a diacylglycerol kinase ζ (DGKZ) was observed to promote metastasis in vitro and in vivo. The gene discussed is PRRT2; the disease is triple-negative breast carcinoma.