To demonstrate the correlation between ARL3 and the malignancy of COAD, we will further investigate other cancer cells with high expression of ARL3. To further investigate the molecular mechanism underlying the connection between Piperine and ARL3, we are considering conducting proteomic and transcriptomic analyses on COAD cells with or without the addition of Piperine. Here, ARL3 is linked to colon adenocarcinoma.