Although global DEGs and IPA exploring the dynamics of immune modulation did not reveal any significantly enriched pathways related to tumour immune microenvironment (Fig. 2b), analysis of the dynamics of curated immune genes and signatures (Supplementary Table 3) revealed increased CD274 expression after rucaparib run-in in three of five responders but not in non-responders (Fig. 2d). The gene discussed is CD274; the disease is neoplasm.