Only a few studies investigated the mRNA levels of genes involved in the initiation of autophagosome formation, such as BECN1, ATG5, or ATG7. To conclude, the available evidence from patients supports the role of inhibition of the autophagic process in the development and progression of MASLD, however, more evidence regarding the stage of autophagy impairment is needed to better understand the pathophysiology of this disease. The gene discussed is ATG5; the disease is metabolic dysfunction-associated steatotic liver disease.