The distribution of TAMs, which were identified on iba1-staining, visually differed between the treatment groups: while animals that received CDNP showed patchy clusters of TAMs at the tumor borders and partially within the tumor core, a homogeneous distribution of TAMs within and in the immediate vicinity of the glioma was observable in mice treated with CDNP-R848 (Fig. 5A). The gene discussed is AIF1; the disease is central nervous system cancer.