A previous study reported that inhibition of LSD1 with polyamine analogs not only increased global levels of H3K4 methylation, but also H3K9ac, an epigenetic mark at active promoters92,93, at the promoters of SFRP1, SFRP5, SFRP5 and GATA5 in human colon carcinoma cells94. Here, SFRP5 is linked to colon carcinoma.