Moreover, the restoration of Tgfb1 expression in MC38 tumor cells (Supplementary Fig. 12A) had a comparable impact to exogenous TGF-β1 in mitigating the tumor suppression (Supplementary Fig. 12B–D) and CD44+CD8+ T cell activation (Supplementary Fig. 12E) induced by Atp6v0a1 depletion. The gene discussed is TGFB1; the disease is neoplasm.