High-fat diet (HFD)-induced obesity downregulates prolyl-4-hydroxylase 3 (PHD3) expression and thus promotes FA uptake and oxidation in CRC cells, depriving the tumor microenvironment (TME) of FAs and, thus, attenuating the FA-supported anti-tumor activities of CD8+ T cells1. This evidence concerns the gene EGLN3 and neoplasm.