Interestingly, while Dac treatment did not alter the growth of MC38 tumors in NOD/SCID mice (Fig. 9C–E), in C57BL/6 J mice it significantly suppressed the growth of MC38 tumors (Fig. 9C–E), reduced TGF-β1 expression in tumor tissue (Fig. 9G), and activated TME-derived CD44+CD8+ T cells (Fig. 9H). Here, TGFB1 is linked to neoplasm.