In addition, we found a significant negative association between methylation levels of TBX15 and obesity (cg14565725, OR 0.9182, CI 0.8332 to 0.9864, p = 0.0004; cg07892597, OR 0.9391, CI 0.8661 to 0.9996, p = 0.0486; cg10703826 OR 0.9336, CI0.8690 to 0.9892, p = 0.0184; and cg24884142, OR 0.8864, CI 0.7909 to 0.9659, p = 0.0042). Here, TBX15 is linked to obesity due to melanocortin 4 receptor deficiency.