In contrast, in P1 glioma cells overexpressing ORC6, “oeORC6-Slc1” and “oeORC6-Slc2,” there was a significant elevation observed in both mRNA and protein expression levels of Cyclin A2, Cyclin B2, and TOP2A (Fig. 7C, D). Here, CCNB2 is linked to central nervous system cancer.