In contrast to P1 glioma cells with scramble control shRNA (“shC”), cells with shRBPJ displayed a remarkable decrease in RBPJ mRNA (Fig. 8C) and protein (Fig. 8D) expression, accompanied by a significant reduction in ORC6 mRNA (Fig. 8C) and protein (Fig. 8D) expression. Here, ORC6 is linked to central nervous system cancer.