In contrast, in P1 glioma cells overexpressing ORC6, “oeORC6-Slc1” and “oeORC6-Slc2,” there was a significant elevation observed in both mRNA and protein expression levels of Cyclin A2, Cyclin B2, and TOP2A (Fig. 7C, D). This evidence concerns the gene MCHR1 and central nervous system cancer.