This led to the development of small molecules that can activate TrkB signaling and mimic the beneficial properties of BDNF, such as 7,8-dihydroxy flavone (7,8-DHF) and its derivative CF3CN, some of the best studied BDNF mimetics that can prevent neurotoxicity in vitro and in vivo, enhance learning, prevent memory impairment and promote axonal regeneration [41–46]. This evidence concerns the gene BDNF and memory impairment.