BDNF and early-onset autosomal dominant Alzheimer disease: Such new translational platforms for human disease, open a unique channel for studying the effects of BDNF on human NSCs and neurons and provide a system to screen potential neurogenic drugs for neurodegenerative diseases and especially AD, while recent work has even highlighted the potential of iPSC-derived NPCs and neurons for studying the connection of adult neurogenesis and Alzheimer disease [17].