In 2017, Wdowiak et al. indicated in their study that anxiety and depression in infertile individuals were associated with higher prolactin and cortisol levels, lower sex hormone-binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEA-S) secretion, and lower sperm volume and quality [82]. The gene discussed is SHBG; the disease is Infertility.