EDN1 and Stroke: The administration of Veratrum alkaloid resulted in a rapid decreased in BP within 30 min, attenuation of renal and cardiovascular damage, and improvement of biochemical indicators such as nitric oxide [NO], endothelin-1 [ET-1], angiotensin II [Ang II)], noradrenaline [NE], etc.)in SHRs, thereby delaying the occurrence of stroke [15].