The four putative FMRP-mediated NGD substrates that did show increased mRNA stability upon Fmr1 and Zfp598 knockdown do encode neuronal proteins (Table S4), all of which could contribute to documented FXS phenotypes (56), including those involved in neurotransmission (Dbh), cell differentiation regulation in the hippocampus (Id3), as well as neuronal migration and axonal projection (Tbr1). Here, DBH is linked to fragile X syndrome.