ITGAM and systemic lupus erythematosus: We do not yet know the effect of rhsB1 on ADAM17 or furin activity but in relation to TLR 7 and/or 8 signaling, CD11b activation has been shown to reduce inflammation and autoimmunity in SLE by suppressing TLR and IFN-I signaling via negative regulation of the NF-κB pathway and increased degradation of MyD88 (60, 61).