Fructose is transported to the liver via GLUT2 and phosphorylated by KHK in the presence of ATP to yield F-1P (48), which is subsequently converted to triglycerides and stored as fat; thus, high fructose consumption is also linked to nonalcoholic fatty liver disease (NAFLD) (49). This evidence concerns the gene KHK and metabolic dysfunction-associated steatotic liver disease.