However, α-Syn is also responsible for the downregulationof i20S.69 α-Syn suppresses the expressionof POMP, a chaperone responsible for i20S assembly and maturation.Induced expression of POMP enhances proteasomal activity and PLK2degradation, alleviating α-Syn aggregation and neuronal lossin PD.69 Recently studies emerged directlyconnecting increased expression of PSMB8 with development of PD.70 Thus, therapies based on the intensificationof i20S assembly seem to be a promising approach in novel PD treatment. This evidence concerns the gene PSMB8 and Parkinson disease.