PSMB9 and Alzheimer disease: This improvementoccurs through the reduction of microglia-mediated inflammation, irrespectiveof Aβ accumulation.58 Other studiesindicated that inhibition of both β1 and LMP2 subunits led todecrease in secretion of inflammatory cytokines from microglial cells,proposing that this intervention could present a novel therapeuticapproach for AD.59